Technology Process of benzyl 5,6,7,8-tetrahydro-2-oxo-2H-1-benzopyran-3-carboxylate
There total 2 articles about benzyl 5,6,7,8-tetrahydro-2-oxo-2H-1-benzopyran-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.1021/ol302942m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trimethylsilyl iodide / chloroform / 22 h / Reflux
1.2: 0.17 h / 25 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C
With
dmap; trimethylsilyl iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; chloroform;
DOI:10.1021/ol302942m
- Guidance literature:
-
trimethylsulfoxonium iodide;
With
sodium hydride;
In
dimethyl sulfoxide; mineral oil;
at 20 ℃;
for 0.5h;
Inert atmosphere;
benzyl 5,6,7,8-tetrahydro-2-oxo-2H-1-benzopyran-3-carboxylate;
In
dimethyl sulfoxide; mineral oil;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/ol302942m
