Methantheline bromide

Base Information

Chemical Name:Methantheline bromide
CAS No.:53-46-3
Molecular Formula:C21H26 N O3 . Br
Molecular Weight:420.346
Hs Code.:2932999099
European Community (EC) Number:200-176-0
NSC Number:32145
UNII:090519SAPF
DSSTox Substance ID:DTXSID7023277
Wikidata:Q27236434
NCI Thesaurus Code:C66112
ChEMBL ID:CHEMBL1200988
Mol file:53-46-3.mol

Synonyms:Banthine;methantheline;methantheline bromide;Vagantin

Suppliers and Price of Methantheline bromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
UlcineBromide
50mg
$ 180.00

Medical Isotopes, Inc.
UlcineBromide
50 mg
$ 650.00

American Custom Chemicals Corporation
METHANTHELINE BROMIDE 95.00%
5MG
$ 497.29

Total 20 raw suppliers

Chemical Property of Methantheline bromide

Chemical Property:

Melting Point:175-176°
Refractive Index:1.6200 (estimate)
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：35.53000
Density:g/cm³
LogP:0.95780
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:419.10961
Heavy Atom Count:26
Complexity:426

Purity/Quality:

99% ^*data from raw suppliers

UlcineBromide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC[N+](C)(CC)CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13.[Br-]
Recent EU Clinical Trials:DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED PROSPECTIVE MULTI-CENTRE PHASE III TRIAL TO ASSESS THE EFFICACY AND SAFETY OF METHANTHELINIUM BROMIDE (VAGANTIN?) IN THE TREATMENT OF FOCAL PALMAR-AXILLARY HYPERHIDROSIS
Uses METHANTHELINE BROMIDE is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis. Ulcine is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.
Clinical Use Methantheline bromide, introduced in 1950, is a potent anticholinergicagent and acts at the nicotinic cholinergic receptors of thesympathetic and parasympathetic systems, as well as at themyoneural junction of the postganglionic cholinergic fibers.Like other quaternary ammonium drugs, methantheline bromideis absorbed incompletely from the GI tract.

Technology Process of Methantheline bromide

There total 4 articles about Methantheline bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-83-9
methyl bromide

: 24539-72-8
N,N-diethylaminoethyl xanthene-9-carboxylate

: 53-46-3
methantheline bromide

Guidance literature:: With butanone;

Reference yield:

: (2-Bromo-ethyl)-diethyl-methyl-ammonium

: 53-46-3
methantheline bromide

Guidance literature:: With water;

Reference yield:

: 82-07-5
xanthene-9-carboxylic acid

: 53-46-3
methantheline bromide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrachloromethane; sulfuric acid

2: acetone

With tetrachloromethane; sulfuric acid; acetone;