Technology Process of C27H28BrF4N3O5
There total 10 articles about C27H28BrF4N3O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
pH=8 - 9;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium iodide / acetonitrile / 20 h / 0 - 20 °C
2: bromine; acetic acid / 2 h
3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
4: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 100 °C
5: boron tribromide / dichloromethane / 3 h / -78 - 20 °C
6: triethylamine / dichloromethane / 20 °C / pH 8 - 9
With
di-isopropyl azodicarboxylate; bromine; boron tribromide; sodium carbonate; acetic acid; triethylamine; triphenylphosphine; sodium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: bromine; acetic acid / 2 h
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 100 °C
4: boron tribromide / dichloromethane / 3 h / -78 - 20 °C
5: triethylamine / dichloromethane / 20 °C / pH 8 - 9
With
di-isopropyl azodicarboxylate; bromine; boron tribromide; sodium carbonate; acetic acid; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;