2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranyl acetic acid

Base Information

• Chemical Name: 2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranyl acetic acid
• CAS No.: 134867-65-5
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• Mol file: 134867-65-5.mol

Synonyms:2-Benzofuranaceticacid, 2,3-dihydro-5-methoxy-4,6,7-trimethyl-, (?à)-; IRFI 048

Chemical Property of 2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranyl acetic acid

Chemical Property:

• Vapor Pressure: 8.56E-08mmHg at 25°C
• Boiling Point: 419.7°Cat760mmHg
• Flash Point: 157.6°C
• PSA: 55.76000
• Density: 1.166g/cm³
• LogP: 2.66640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranyl acetic acid

There total 1 articles about 2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranyl acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranacetic acid methyl ester (128232-19-9) → (+/-)-2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranacetic acid (134867-65-5)

Guidance literature:

With sodium hydroxide; for 1h; Ambient temperature;

DOI:10.1002/jhet.5570300318

Reference yield:

(+/-)-2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranacetic acid (134867-65-5) → (+/-)-2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranethanol p-toluenesulfonate (154954-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: pyridine / 3 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/jhet.5570300318

upstream raw materials:

(+/-)-2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranacetic acid methyl ester

Downstream raw materials:

(+/-)-2,3-dihydro-5-methoxy-4,6,7-trimethyl-2-benzofuranethanol p-toluenesulfonate

Refernces