(E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

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Chemical Name:(E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide
CAS No.:1370748-94-9
Molecular Formula:C₂₄H₂₅N₅O₃S
Molecular Weight:463.56
Hs Code.:

Synonyms:(E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

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Chemical Property of (E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

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Technology Process of (E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

There total 5 articles about (E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1312592-14-5
C₁₃H₁₃NO₃

: 1370749-03-3
2-(1-azido-2-methylpropyl)benzo[d]thiazole

: 1370748-94-9
(E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

Guidance literature:: With triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm201496g

Reference yield:

: 13734-41-3,22838-58-0,54895-12-4
N-Boc-(S/R)-valine

: 1370748-94-9
(E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

2.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

5.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm201496g

Reference yield:

: tert-butyl N-[1-(2-mercaptophenylcarbamoyl)-2-methylpropyl]carbamate

: 1370748-94-9
(E)-N-(4-methoxybenzyloxy)-3-(1-(1-(benzo[d]thiazol-2-yl)-2-methylpropyl)-1H-1,2,3-triazol-4-yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm201496g