Synonyms:xanthen-9-ol;xanthydrol
99% *data from raw suppliers
Xanthydrol *data from reagent suppliers
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There total 25 articles about 9H-Xanthen-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 100.0%
Reference yield: 91.0%
Reference yield: 90.0%
The research focuses on the synthesis and evaluation of cysteinyl-flavan-3-ol conjugates derived from grape procyanidins. These new antioxidant compounds were prepared by depolymerizing grape polymeric flavanols in the presence of cysteine and were assessed for their antiradical/antioxidant and antiproliferative properties. The reactants included grape polymeric flavanols, cysteine, and other reagents necessary for the depolymerization process and subsequent purification. The analyses used to characterize and evaluate the compounds comprised cation-exchange chromatography, preparative reversed-phase chromatography, nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), and theoretical calculations of bond dissociation enthalpies (BDEs). The experiments also involved the DPPH assay to measure the free radical scavenging activity and an MTT assay to evaluate the antiproliferative activity on human colon carcinoma HT29 cells. The results indicated that the new cysteinyl derivatives showed improved antioxidant efficiency and antiproliferative effects compared to the underivatised (-)-epicatechin.
The research discusses the reactions of vinylidenecyclopropanes (VDCPs) with xanthydrol and xanthene, exploring their ring-opening reactions under specific conditions to yield conjugate triene derivatives. The study aimed to investigate the effects of different substituents on the reaction outcomes and to propose plausible reaction mechanisms based on previous literature and control experiments. The researchers used BF3·OEt2 as a catalyst with xanthydrol and DDQ with xanthene, conducting the reactions in 1,2-dichloroethane (DCE) at 0°C. The reactions resulted in moderate to good yields of conjugate triene derivatives, which were further transformed into novel spiro-alkanes using BF3·OEt2 at 70°C. The study concluded that these reactions provided a versatile method for synthesizing complex molecular structures and shed light on the reaction mechanisms involved, with further work underway to elucidate the mechanistic details and determine the scope and limitations of the reaction.
The research discusses the synthesis and inhibitory activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin against ribonuclease A (RNase A), with the aim of increasing the number of phenolic hydroxyl groups to enhance inhibition. The study concluded that these novel conjugates were more effective inhibitors of RNase A than catechin and epicatechin, highlighting the importance of phenolic hydroxyl groups in inhibiting ribonucleolytic activity. The research also explored the compounds' anti-angiogenic activity through the chorioallantoic membrane (CAM) assay, finding that the epicatechin-based polyphenols showed inhibition of angiogenin-induced angiogenesis. Chemicals used in the synthesis process included (+)-catechin, (-)-epicatechin, phloroglucinol, resorcinol, LiBr, and various protecting groups such as benzyl ether. The study employed techniques like fluorescence studies, protein-ligand docking, and CD spectroscopic studies to evaluate binding parameters and interactions.
The research focused on the isolation and structural elucidation of proanthocyanidins from the root bark of Cinnamomum sieboldii Meisner, a plant belonging to the Lauraceae family. The purpose of the study was to determine the structures of proanthocyanidin trimers and to clarify the composition of higher oligomeric proanthocyanidins in this plant. The researchers used acid-catalyzed thiolytic degradation, proton and carbon-13 nuclear magnetic resonance analyses to establish the structures of the compounds. They isolated a trimer, two tetramers, and a pentamer, and demonstrated the presence of (-)-epicatechin, (+)-catechin, and known proanthocyanidins B-1, B-2, and B-5, among others. The conclusions highlighted that the root bark of C. sieboldii contains large amounts of proanthocyanidins with a doubly linked bisflavanoid (A-type) unit, accompanied by minor singly linked procyanidins, and that the composition of proanthocyanidins in C. sieboldii is similar to that in C. zeylanicum, which is of chemotaxonomical interest. The study also noted that proanthocyanidin trimers 1 and 9 have a sweet taste, contrasting with the astringent taste of other oligomeric proanthocyanidins.
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