(S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate
CAS No.:1239447-27-8
Molecular Formula:C₂₅H₄₀N₂O₄Si
Molecular Weight:460.689
Hs Code.:

Synonyms:(S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate

There total 2 articles about (S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1031367-36-8
(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine

: 61350-60-5,61350-62-7,89705-40-8,106709-50-6
(S)-benzyloxycarbonyl-proline acid chloride

: 1239447-27-8
(S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.05.012

Reference yield:

: 1031367-36-8
(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1239447-27-8
(S)-benzyl 2-((S)-2-((tert-butyldimethylsilyloxy)methyl)-piperidine-1-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: (2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)piperidine; N-Benzyloxycarbonyl-L-proline; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

With 4-methyl-morpholine; In dichloromethane; N,N-dimethyl-formamide; for 96h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.05.012