tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate
CAS No.:871577-22-9
Molecular Formula:C₂₇H₃₇NO₇
Molecular Weight:487.593
Hs Code.:

Synonyms:tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

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Chemical Property of tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

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Technology Process of tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

There total 5 articles about tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: tert-butyl (3E)-1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbut-3-enylcarbamate

: 871577-22-9
tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;
DOI:10.1055/s-2005-872109

Reference yield:

: 253353-08-1
1,1-dimethylethyl α-(1,1-dimethylethoxy)carbonylamino-3,4-dioxo-2-(1-methylethoxy)-1-cyclobutene-1-acetate

: 871577-22-9
tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / acetonitrile / 0.08 h / 20 °C

1.2: 100 percent / tetrabutylammonium iodide / acetonitrile / 0.5 h / 20 °C

2.1: 70 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1055/s-2005-872109

Reference yield:

: tert-butoxycarbonylamino-(1,2-diisopropoxy-3,4-dioxo-cyclobutyl)-acetic acid tert-butyl ester

: 871577-22-9
tert-butyl 1-(tert-butoxycarbonyl)-1-(2-isopropoxy-3,4-dioxocyclobut-1-enyl)-4-phenylbutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / aq. HCl / CH₂Cl₂ / 4 h / 20 °C

2.1: K₂CO₃ / acetonitrile / 0.08 h / 20 °C

2.2: 100 percent / tetrabutylammonium iodide / acetonitrile / 0.5 h / 20 °C

3.1: 70 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1055/s-2005-872109