2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine

Base Information

• Chemical Name: 2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine
• CAS No.: 1395030-58-6
• Molecular Formula: C₁₃H₁₆F₂N₂
• Molecular Weight: 238.28

Synonyms:2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine

Chemical Property of 2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine

Chemical Property:

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Technology Process of 2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine

There total 2 articles about 2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-difluoro-2-iodoethane (598-39-0) + (R)-5-chloro-6-(pyrrolidin-3-yloxy)pyridine-3-sulfonamide + 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine trifluoroacetate (1395030-57-5) + C13H9F3N4S (1254165-70-2) + 1H-pyrrolo[3,2-b]pyridine-6-chloro-5-carboxylic acid ethyl ester (872355-69-6) + 1,1-difluoro-2-iodoethane (598-39-0) → N-(4-bromo-2-(trifluoromethoxy)benzyl)-2-(2,2-difluoroethyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide (1241826-85-6) + (R)-5-chloro-6-(1-(2,2-difluoroethyl)pyrrolidin-3-yloxy)pyridine-3-sulfonamide + methyl 1-(2,2-difluoroethyl)-1H-indole-5-carboxylate (1252782-51-6) + C15H11F5N4S (1254165-78-0) + 2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine (1395030-58-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 16h;

Reference yield:

1,1-difluoro-2-iodoethane (598-39-0) + (R)-5-chloro-6-(pyrrolidin-3-yloxy)pyridine-3-sulfonamide + 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine trifluoroacetate (1395030-57-5) + C13H9F3N4S (1254165-70-2) + 1H-pyrrolo[3,2-b]pyridine-6-chloro-5-carboxylic acid ethyl ester (872355-69-6) + 1,1-difluoro-2-iodoethane (598-39-0) → N-(4-bromo-2-(trifluoromethoxy)benzyl)-2-(2,2-difluoroethyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide (1241826-85-6) + (R)-5-chloro-6-(1-(2,2-difluoroethyl)pyrrolidin-3-yloxy)pyridine-3-sulfonamide + methyl 1-(2,2-difluoroethyl)-1H-indole-5-carboxylate (1252782-51-6) + C15H11F5N4S (1254165-78-0) + 2'-(2,2-difluoroethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine (1395030-58-6) + 6-chloro-1-(2,2-difluoro-ethyl)-1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid ethyl ester (1387561-46-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 16h;

upstream raw materials:

1,1-difluoro-2-iodoethane

2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-amine trifluoroacetate

C₁₃H₉F₃N₄S

1H-pyrrolo[3,2-b]pyridine-6-chloro-5-carboxylic acid ethyl ester

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