(R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

Base Information

Chemical Name:(R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate
CAS No.:1337527-22-6
Molecular Formula:C₅₈H₈₄N₂O₉S
Molecular Weight:985.379
Hs Code.:

Synonyms:(R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

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Chemical Property of (R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

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Technology Process of (R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

There total 4 articles about (R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5515-00-4
benzyl (6-amino)hexaneate hydrochloride

: 1337526-68-7
(5R,9R)-9-(dodecanoyloxy)-1-(9H-fluoren-9-yl)-3,12-dioxo-2,11-dioxa-7-thia-4-azatricosane-5-carboxylic acid

: 1337527-22-6
(R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

Guidance literature:: (5R,9R)-9-(dodecanoyloxy)-1-(9H-fluoren-9-yl)-3,12-dioxo-2,11-dioxa-7-thia-4-azatricosane-5-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

benzyl (6-amino)hexaneate hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 139573-71-0
(R)-tert-butyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-((R)-2,3-dihydroxypropylthio)propanoate

: 1337527-22-6
(R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Cooling with ice

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 139592-37-3
(2R,2‘R)-di-tert-butyl 3,3‘-disulfanediylbis(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoate)

: 1337527-22-6
(R)-3-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(6-(benzyloxy)-6-oxohexylamino )-3-oxopropylthio)propane-1,2-diyl didodecanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydroxide / tert-butyl alcohol / 20 °C

2.2: 15 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 20 °C

With pyridine; 1,4-dithio-erythritol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;