(4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane

Base Information

Chemical Name:(4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane
CAS No.:719288-97-8
Molecular Formula:C₂₀H₃₄O₃Si
Molecular Weight:350.574
Hs Code.:

Synonyms:(4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane

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Chemical Property of (4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane

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Technology Process of (4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane

There total 2 articles about (4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 85272-31-7
di-tert-butylsilyl bis(trifluoromethanesulfonate)

: 917-54-4
methyllithium

: 78513-07-2,78513-12-9,78513-15-2,84621-89-6,87172-27-8,95672-91-6,98048-62-5,98048-63-6,78469-85-9
((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol

: 719288-97-8
(4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane

Guidance literature:: methyllithium; ((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol; With copper(l) iodide; In diethyl ether; at -40 ℃; for 5h;

di-tert-butylsilyl bis(trifluoromethanesulfonate); With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 3h; Further stages.;
DOI:10.1016/j.tetlet.2004.04.034

Reference yield:

: 81028-03-7
(Z)-4-benzyloxy-but-2-en-1-ol

: 719288-97-8
(4R,5S)-4-Benzyloxymethyl-2,2-di-tert-butyl-5-methyl-[1,3,2]dioxasilinane

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ti(O-i-Pr)4; (-)-DET / CH₂Cl₂ / 1 h / -30 °C

1.2: t-BuOOH / CH₂Cl₂ / 96 h / -30 °C

2.1: CuI / diethyl ether / 5 h / -40 °C

2.2: 58 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 20 °C

With titanium(IV) isopropylate; copper(l) iodide; (-)-diethyl tartrate; In diethyl ether; dichloromethane; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tetlet.2004.04.034