5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

• Chemical Name: 5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS No.: 882161-82-2
• Molecular Formula: C₁₄H₁₃ClO₄
• Molecular Weight: 280.708
• Mol file: 882161-82-2.mol

Synonyms:5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Chemical Property of 5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 1 articles about 5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

cycl-isopropylidene malonate (2033-24-1) + 1-(2-chlorophenyl)ethanone (2142-68-9) → 5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (882161-82-2)

Guidance literature:

With pyridine; titanium tetrachloride; In tetrahydrofuran; at 0 - 20 ℃; for 20h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202014489

Reference yield: 80.0%

5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (882161-82-2) + diphenyl acetylene (501-65-5) → 4-(2-chlorophenyl)-8,8-dimethyl-1,2-diphenyl-7,9-dioxaspiro[4.5]deca-1,3-diene-6,10-dione

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In acetonitrile; at 80 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03982

Reference yield: 70.0%

5-[1-(2-chlorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (882161-82-2) + dihydro-4,4-dimethyl-2,3-furandione (98136-03-9) → C16H15ClO4

Guidance literature:

With triethylamine; In dichloromethane; at 10 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.202100559

upstream raw materials:

cycl-isopropylidene malonate

1-(2-chlorophenyl)ethanone

Downstream raw materials:

5-[1-(2-chlorophenyl)-1-methylethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione