4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile

Base Information

Chemical Name:4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile
CAS No.:1001397-62-1
Molecular Formula:C₁₃H₇ClF₂N₄
Molecular Weight:292.675
Hs Code.:

Synonyms:4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile

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Chemical Property of 4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile

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Technology Process of 4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile

There total 1 articles about 4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1001397-61-0
2-[4-chloro-6-((4-cyano-2,5-difluorophenyl){[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-pyrimidinyl]ethyl methanesulfonate

: 1001397-62-1
4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile

Guidance literature:: 2-[4-chloro-6-((4-cyano-2,5-difluorophenyl){[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-pyrimidinyl]ethyl methanesulfonate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 13.0%

: 832714-37-1
1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ol

: 1001397-62-1
4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile

: 1001397-63-2
2,5-difluoro-4-[4-({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}oxy)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile

Guidance literature:: 1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

4-(4-chloro-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-difluorobenzonitrile; In tetrahydrofuran; for 3h; Heating / reflux;