N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester

Base Information

• Chemical Name: N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester
• CAS No.: 133166-99-1
• Molecular Formula: C₂₀H₂₁Cl₃N₂O₃
• Molecular Weight: 443.757

Synonyms:N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester

Chemical Property of N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester

There total 3 articles about N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

6-chloro-2,4-dioxo-2H-3,1-benzoxazine-1(4H)-acetic acid 1,1-dimethylethyl ester (133166-98-0) + 3,4-dichlorobenzyl amine (102-49-8) → N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester (133166-99-1)

Guidance literature:

With triethylamine; In toluene; at 100 ℃; for 0.5h;

DOI:10.1021/jm00108a038

Reference yield:

5-Chloroisatoic anhydride (4743-17-3) → N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester (133166-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH (80percent dispersion in oil) / 1.) DMF, 2 h, 2.) 12 h

2: 85.5 percent / Et₃N / toluene / 0.5 h / 100 °C

With sodium hydride; triethylamine; In toluene;

DOI:10.1021/jm00108a038

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → N-<4-chloro-2-<<<(3,4-dichlorophenyl)methyl>amino>carbonyl>phenyl>glycine 1,1-dimethylethyl ester (133166-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH (80percent dispersion in oil) / 1.) DMF, 2 h, 2.) 12 h

2: 85.5 percent / Et₃N / toluene / 0.5 h / 100 °C

With sodium hydride; triethylamine; In toluene;

DOI:10.1021/jm00108a038

upstream raw materials:

6-chloro-2,4-dioxo-2H-3,1-benzoxazine-1(4H)-acetic acid 1,1-dimethylethyl ester

3,4-dichlorobenzyl amine

5-Chloroisatoic anhydride

bromoacetic acid tert-butyl ester

Downstream raw materials:

[6-Chloro-3-(3,4-dichloro-benzyl)-4-oxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid

[6-Chloro-3-(3,4-dichloro-benzyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid

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