(1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester
• CAS No.: 1033756-03-4
• Molecular Formula: C₁₄H₁₈FNO₂
• Molecular Weight: 251.301
• Mol file: 1033756-03-4.mol

Synonyms:(1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

Chemical Property of (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester

There total 5 articles about (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester hydrochloride + 4-fluorobenzaldehyde (459-57-4) → (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester (1033756-03-4)

Guidance literature:

With sodium acetate; sodium cyanoborohydride; In methanol; at 25 ℃; for 16h; Product distribution / selectivity; 4? molecular sieves;

Reference yield:

(1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester (154460-33-0,170421-23-5) + 4-fluorobenzaldehyde (459-57-4) → (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester (1033756-03-4)

Guidance literature:

(1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester; 4-fluorobenzaldehyde; In methanol; at 20 ℃; for 0.0833333h;

With sodium cyanoborohydride; acetic acid; In methanol; at 20 - 25 ℃; for 16h;

Reference yield:

(1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester hydrochloride (119993-55-4) + 4-fluorobenzaldehyde (459-57-4) → (1R,2S)-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid methyl ester (1033756-03-4)

Guidance literature:

With sodium borohydrid; magnesium sulfate; triethylamine; In tetrahydrofuran; methanol; ethyl acetate;

upstream raw materials:

4-fluorobenzaldehyde

(1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester

(1R,2S)-2-amino-cyclopentanecarboxylic acid methyl ester hydrochloride

(1R,2S)-2-Amino-cyclopentane-1-carboxylic acid hydrochloride

Downstream raw materials:

(1R,2S)-2-{(4-fluoro-benzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-acetyl]-amino}-cyclopentanecarboxylic acid methyl ester