(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

Base Information

Chemical Name:(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate
CAS No.:69661-07-0
Molecular Formula:C₂₉H₃₅NO₆S
Molecular Weight:525.666
Hs Code.:

Synonyms:(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

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Chemical Property of (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

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Technology Process of (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

There total 6 articles about (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 69661-06-9,69686-37-9
(-)-3-methoxy-14α-hydroxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-17α-yl N-mesyl-(S)-phenylalaninate

: 69661-07-0
(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

Guidance literature:: With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In benzene; for 5h; Ambient temperature;
DOI:10.1016/0040-4020(80)80161-X

Reference yield:

: 25221-98-1
2-[(2E)-2-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione

: 69661-07-0
(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium tri-t-butoxyaluminum hydride, 2.) LAH / 1.)2.) THF, (-68)-(-72) deg C, 1 h

2: 22 percent / pyridine / tetrahydrofuran / Ambient temperature

3: 80 percent / dicyclohexyl carbodiimide, dimethyl sulfoxide, pyridine, trifluoroacetic acid / benzene / 5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; lithium tri(t-butoxy)aluminum hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4020(80)80161-X

Reference yield:

: 85760-98-1
3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diol

: 69661-07-0
(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14-on-17α-yl N-mesyl-(S)-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / pyridine / tetrahydrofuran / Ambient temperature

2: 80 percent / dicyclohexyl carbodiimide, dimethyl sulfoxide, pyridine, trifluoroacetic acid / benzene / 5 h / Ambient temperature

With pyridine; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4020(80)80161-X