2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol

Base Information

• Chemical Name: 2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol
• CAS No.: 1150847-52-1
• Molecular Formula: C₂₀H₂₀F₄N₂O
• Molecular Weight: 380.385

Synonyms:2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol

Chemical Property of 2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol

Chemical Property:

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Technology Process of 2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol

There total 2 articles about 2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinoline-6-carbaldehyde (1150847-21-4) + ammonium chloride → 2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol (1150847-52-1)

Guidance literature:

With tetrabutyl ammonium fluoride; trifluoroacetic acid; In tetrahydrofuran; methanol; water; (trifluoromethyl)trimethylsilane;

Reference yield:

(trifluoro methyl) magnesiumbromide (959844-08-7) + (5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinoline-6-carbaldehyde (1150847-21-4) → 2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol (1150847-52-1)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm901551w

Reference yield:

2,2,2-trifluoro-1-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)ethanol (1150847-52-1) → C20H18F4N2O

Guidance literature:

With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm901551w

upstream raw materials:

(trifluoro methyl) magnesiumbromide

(5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinoline-6-carbaldehyde

Downstream raw materials:

(S)-1,1,1-trifluoro-2-[(5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl]propan-2-ol

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