Technology Process of 2-(4-decylphenyl)-4-methoxy-6-((trimethylsilyl)ethynyl)isoindoline-1,3-dione
There total 11 articles about 2-(4-decylphenyl)-4-methoxy-6-((trimethylsilyl)ethynyl)isoindoline-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1246/cl.2012.1566
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid; nitric acid / 1 h / 0 °C
2.1: platinum on activated charcoal; hydrogen / tetrahydrofuran / 24 h / 20 °C / 760.05 Torr
3.1: sulfuric acid; sodium nitrite / water / 1 h / 0 °C
3.2: 5 h / 50 °C
4.1: potassium carbonate / acetone / 6 h / 70 °C
5.1: water; tert-butyl alcohol / 24 h / 110 °C
5.2: pH 1
6.1: acetic anhydride / 6 h / 160 °C
7.1: toluene / 24 h / 140 °C
8.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; platinum on activated charcoal; hydrogen; nitric acid; acetic anhydride; potassium carbonate; triethylamine; sodium nitrite;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
8.1: |Sonogashira Cross-Coupling;
DOI:10.1246/cl.2012.1566
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 6 h / 70 °C
2.1: water; tert-butyl alcohol / 24 h / 110 °C
2.2: pH 1
3.1: acetic anhydride / 6 h / 160 °C
4.1: toluene / 24 h / 140 °C
5.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; acetic anhydride; potassium carbonate; triethylamine;
In
water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
5.1: |Sonogashira Cross-Coupling;
DOI:10.1246/cl.2012.1566
