Technology Process of 4-ethyl-7-methoxy-3-(4-methoxyphenyl)isocoumarine
There total 5 articles about 4-ethyl-7-methoxy-3-(4-methoxyphenyl)isocoumarine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
at 20 ℃;
for 6h;
DOI:10.1016/j.bmc.2005.07.014
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / triethylamine; CuI; tetrabutylammonium iodide / Pd(PPh3)4 / acetonitrile / 4 h / Heating
2: 73 percent / I2 / acetonitrile / 2 h / 20 °C
3: 76 percent / (t-Bu)3P; CsF / Pd2(dba)2 / dioxane / 12 h / 80 °C
4: 100 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C
With
copper(l) iodide; tri-tert-butyl phosphine; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; triethylamine; cesium fluoride;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0); palladium bis(dibenzylideneacetone)palladium(0);
In
1,4-dioxane; ethanol; acetonitrile;
1: Sonogashira coupling / 3: Stille coupling;
DOI:10.1016/j.bmc.2005.07.014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 73 percent / I2 / acetonitrile / 2 h / 20 °C
2: 76 percent / (t-Bu)3P; CsF / Pd2(dba)2 / dioxane / 12 h / 80 °C
3: 100 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C
With
tri-tert-butyl phosphine; hydrogen; iodine; cesium fluoride;
palladium on activated charcoal; palladium bis(dibenzylideneacetone)palladium(0);
In
1,4-dioxane; ethanol; acetonitrile;
2: Stille coupling;
DOI:10.1016/j.bmc.2005.07.014
