3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

Base Information

Chemical Name:3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester
CAS No.:737800-01-0
Molecular Formula:C₁₈H₂₄O₄S₂
Molecular Weight:368.518
Hs Code.:

Synonyms:3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

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Chemical Property of 3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

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Technology Process of 3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

There total 1 articles about 3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 539-74-2
Ethyl 3-bromopropionate

: 104863-73-2
2-Benzyloxy-1-[1,3]dithian-2-yl-ethanone

: 737800-01-0
3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

Guidance literature:: 2-Benzyloxy-1-[1,3]dithian-2-yl-ethanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

Ethyl 3-bromopropionate; In tetrahydrofuran; at 20 ℃; for 24h; Further stages.;
DOI:10.1016/j.tetlet.2004.05.089

Reference yield: 60.0%

: 737800-01-0
3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

: 737799-94-9
3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid

Guidance literature:: With potassium hydroxide; In methanol; at 0 ℃; for 1h;
DOI:10.1016/j.tetlet.2004.05.089

Reference yield:

: 737800-01-0
3-[2-(2-Benzyloxy-acetyl)-[1,3]dithian-2-yl]-propionic acid ethyl ester

: (2R,3R)-tert butyl 2-(benzyloxymethyl)-3-hydroxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / aq. KOH / methanol / 1 h / 0 °C

2: 57 percent / diisopropyl ether / 36 h / Heating

3: 68 percent / NBS / acetone; H₂O / 0.25 h / -30 °C

4: 87 percent / CeCl₃*7H₂O; NaBH₄ / ethanol; tetrahydrofuran / 1.5 h / 20 °C

5: 57 percent / BH₃*THF / tetrahydrofuran / 24 h / 20 °C

6: 72 percent / hydrogen / Pd(OH)2/C / ethyl acetate / 25 °C

With potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; cerium(III) chloride; borane-THF; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; di-isopropyl ether; water; ethyl acetate; acetone; 4: Luche reduction;
DOI:10.1016/j.tetlet.2004.05.089