methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

Base Information

Chemical Name:methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate
CAS No.:1428559-12-9
Molecular Formula:C₂₂H₁₇N₅O₃S
Molecular Weight:431.475
Hs Code.:

Synonyms:methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

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Chemical Property of methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

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Technology Process of methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

There total 4 articles about methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 292057-70-6
3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indole

: 1490-25-1
succinic acid monomethylester chloride

: 1428559-12-9
methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.11.002

Reference yield: 81.0%

: 1428559-12-9
methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1428559-12-9
methyl 4”-(3-((2’-cyanobenzyl)thio)-5H-[1,2,4]triazino[5,6-b]indol-5-yl)-4’‘-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / water / 16 h / Reflux

2: triethylamine / methanol / 16 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; triethylamine; In methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2014.11.002