1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one

Base Information

• Chemical Name: 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
• CAS No.: 138923-86-1
• Molecular Formula: C₃₈H₃₃Cl₂F₂N₅O
• Molecular Weight: 684.616

Synonyms:1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one

Chemical Property of 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one

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Technology Process of 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one

There total 6 articles about 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(2-chloroethyl)imidazolidin-2-one (2387-20-4) + 4,4-bis<5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>piperidine (138923-85-0) → 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one (138923-86-1)

Guidance literature:

With potassium carbonate; potassium iodide; In various solvent(s); for 16h; Heating;

DOI:10.1021/jm00084a014

Reference yield:

4-piperidone hydrochloride (41979-39-9) → 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one (138923-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / CH₃SO₂OH, AcOH / 0.25 h / Heating

2: 76 percent / K₂CO₃, KI / various solvent(s) / 16 h / Heating

With methanesulfonic acid; potassium carbonate; acetic acid; potassium iodide; In various solvent(s);

DOI:10.1021/jm00084a014

Reference yield:

1-(4-fluorophenyl)-5-chloroindole (138900-22-8) → 1-(2-{4,4-Bis-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one (138923-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / CH₃SO₂OH, AcOH / 0.25 h / Heating

2: 76 percent / K₂CO₃, KI / various solvent(s) / 16 h / Heating

With methanesulfonic acid; potassium carbonate; acetic acid; potassium iodide; In various solvent(s);

DOI:10.1021/jm00084a014

upstream raw materials:

1-(2-chloroethyl)imidazolidin-2-one

4,4-bis<5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>piperidine

4-piperidone hydrochloride

1-(4-fluorophenyl)-5-chloroindole

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