((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

Base Information

Chemical Name:((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol
CAS No.:861996-70-5
Molecular Formula:C₃₁H₄₁NO₃S
Molecular Weight:507.737
Hs Code.:

Synonyms:((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

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Chemical Property of ((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

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Technology Process of ((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

There total 5 articles about ((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 861996-66-9
1-(Toluene-4-sulfonyl)-2-[2-((1S,4aS,8aS)-5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-ethyl]-1H-indole

: 861996-70-5
((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

Guidance literature:: 1-(Toluene-4-sulfonyl)-2-[2-((1S,4aS,8aS)-5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-ethyl]-1H-indole; With B₂H₆-THF; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/chem.200401220

Reference yield:

: 861996-62-5
1-[1-(Toluene-4-sulfonyl)-1H-indol-2-yl]-2-((1S,4aS,8aS)-5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-ethanol

: 861996-70-5
((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 400 mg / CH₂Cl₂

2.1: 180 mg / Bu₃SnH; AIBN / toluene / Heating

3.1: B₂H₆*THF / tetrahydrofuran / 0 - 20 °C

3.2: 77 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 1 h / 0 °C

With 2,2'-azobis(isobutyronitrile); B₂H₆-THF; tri-n-butyl-tin hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.200401220

Reference yield:

: imidazole-1-carbothioic acid O-[1-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-2-(5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-ethyl] ester

: 861996-70-5
((1S,2S,4aS,8aR)-5,5,8a-Trimethyl-1-{2-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-decahydro-naphthalen-2-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 180 mg / Bu₃SnH; AIBN / toluene / Heating

2.1: B₂H₆*THF / tetrahydrofuran / 0 - 20 °C

2.2: 77 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 1 h / 0 °C

With 2,2'-azobis(isobutyronitrile); B₂H₆-THF; tri-n-butyl-tin hydride; In tetrahydrofuran; toluene;
DOI:10.1002/chem.200401220