[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane
CAS No.:851121-81-8
Molecular Formula:C₃₄H₃₉N₃O₄Si
Molecular Weight:581.787
Hs Code.:

[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-<i>tert</i>-butyl-diphenyl-silane

Synonyms:[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

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Chemical Property of [5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

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Technology Process of [5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

There total 7 articles about [5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851121-80-7
2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethanol

: 851121-81-8
[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

Guidance literature:: With diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; toluene; at 50 ℃; for 36h;
DOI:10.1021/ja050203t

Reference yield:

: 851121-78-3
(5-bromo-3,4-dimethoxy-2-methyl-phenoxy)-tert-butyl-diphenyl-silane

: 851121-81-8
[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane; toluene / 0.33 h / -78 °C

1.2: 80 percent / toluene; tetrahydrofuran; hexane / 0.83 h / -78 °C

2.1: TEA; formic acid; (R,R)-(TosHN-CHPh-CHPh-NH₂) / (RuCl₂)2(p-cymene) / dimethylformamide / 48 h / 40 °C

3.1: DPPA; DBU / toluene; dimethylformamide / 36 h / 50 °C

With n-butyllithium; formic acid; TEA; diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja050203t

Reference yield:

: 851121-79-4
2-benzyloxy-1-[5-(tert-butyl-diphenyl-silanyloxy)-2,3-dimethoxy-4-methyl-phenyl]-ethanone

: 851121-81-8
[5-(1-azido-2-benzyloxy-ethyl)-3,4-dimethoxy-2-methyl-phenoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: TEA; formic acid; (R,R)-(TosHN-CHPh-CHPh-NH₂) / (RuCl₂)2(p-cymene) / dimethylformamide / 48 h / 40 °C

2: DPPA; DBU / toluene; dimethylformamide / 36 h / 50 °C

With formic acid; TEA; diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja050203t