4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

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Chemical Name:4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide
CAS No.:1620147-21-8
Molecular Formula:C₃₄H₃₄F₃N₇O₂
Molecular Weight:629.685
Hs Code.:

Synonyms:4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

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Chemical Property of 4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

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Technology Process of 4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

There total 9 articles about 4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1620147-21-8
4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Reflux;

Reference yield: 46.0%

: 1616369-01-7
4-amino-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

: 1620147-19-4
2-chloro-5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidine

: 1620147-21-8
4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 150 ℃; for 4h; Microwave irradiation;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 1616369-00-6
N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4-nitrobenzamide

: 1620147-21-8
4-((5-methyl-4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)-N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2014.05.066