tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

Base Information

Chemical Name:tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate
CAS No.:402509-08-4
Molecular Formula:C₃₈H₅₄ClN₃O₄Si
Molecular Weight:680.403
Hs Code.:

tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

Synonyms:tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

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Chemical Property of tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

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Technology Process of tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

There total 9 articles about tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 402508-87-6
2-(4-aminophenyl)-N-4-methylbenzylacetamide

: 174891-03-3
1,1-dimethylethyl ((2R)-2-(3-chlorophenyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)[(1R)-1-methyl-2-oxoethyl]carbamate

: 402509-08-4
tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm0101500

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 402509-08-4
tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CDI / CH₂Cl₂ / 0.75 h

1.2: 53 percent / CH₂Cl₂ / 1 h

2.1: 66 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 20 °C / 760.05 Torr

3.1: 82 percent / NaBH(OAc)3; AcOH / CH₂Cl₂ / 16 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In ethanol; dichloromethane;
DOI:10.1021/jm0101500

Reference yield:

: 349411-17-2
2-(4-nitrophenyl)-N-4-methylbenzylacetamide

: 402509-08-4
tert-butyl (2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl[(1R)-1-methyl-2-(4-{2-[(4-methylbenzyl)amino]-2-oxoethyl}anilino)ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 20 °C / 760.05 Torr

2: 82 percent / NaBH(OAc)3; AcOH / CH₂Cl₂ / 16 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 10percent Pd/C; In ethanol; dichloromethane;
DOI:10.1021/jm0101500