p-Methoxy-α-phenylhydrocinnamic acid hydrazide

Base Information

• Chemical Name: p-Methoxy-α-phenylhydrocinnamic acid hydrazide
• CAS No.: 58973-44-7
• Molecular Formula: C16H18N2O2
• Molecular Weight: 270.33
• Mol file: 58973-44-7.mol

Synonyms:

Chemical Property of p-Methoxy-α-phenylhydrocinnamic acid hydrazide

Chemical Property:

• Vapor Pressure: 3.03E-09mmHg at 25°C
• Boiling Point: 476.5°C at 760 mmHg
• Flash Point: 242°C
• PSA: 67.84000
• Density: 1.156g/cm³
• LogP: 3.55200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Methoxy-α-phenylhydrocinnamic acid hydrazide

There total 1 articles about p-Methoxy-α-phenylhydrocinnamic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(4-methoxyphenyl)-2-phenylpropanoate (109250-59-1) → 3-(4-methoxy-phenyl)-2-phenyl-propionic acid hydrazide (58973-44-7)

Guidance literature:

With hydrazine hydrate;

Reference yield:

3-(4-methoxy-phenyl)-2-phenyl-propionic acid hydrazide (58973-44-7) → {5-[2-(4-Methoxy-phenyl)-1-phenyl-ethyl]-[1,3,4]oxadiazol-2-ylsulfanyl}-acetic acid (78613-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.1 M potassium hydroxide / ethanol / Heating

2: 0.06 M sodium hydroxide, 0.033 M sodium bicarbonate / dimethylformamide; H₂O / Heating

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

3-(4-methoxy-phenyl)-2-phenyl-propionic acid hydrazide (58973-44-7) → {5-[2-(4-Methoxy-phenyl)-1-phenyl-ethyl]-[1,3,4]oxadiazol-2-ylsulfanyl}-acetic acid ethyl ester (78613-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.1 M potassium hydroxide / ethanol / Heating

2: K₂CO₃ / dimethylformamide / 4 h / Heating

With potassium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 3-(4-methoxyphenyl)-2-phenylpropanoate

Downstream raw materials:

5-[2-(4-Methoxy-phenyl)-1-phenyl-ethyl]-3H-[1,3,4]oxadiazole-2-thione

{5-[2-(4-Methoxy-phenyl)-1-phenyl-ethyl]-[1,3,4]oxadiazol-2-ylsulfanyl}-acetic acid

{5-[2-(4-Methoxy-phenyl)-1-phenyl-ethyl]-[1,3,4]oxadiazol-2-ylsulfanyl}-acetic acid ethyl ester