Technology Process of 5-(1,3-dioxoisoindolin-2-yl)-2-((1,3-dioxoisoindolin-2-yl)methyl)pentanoic acid
There total 1 articles about 5-(1,3-dioxoisoindolin-2-yl)-2-((1,3-dioxoisoindolin-2-yl)methyl)pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 2 h / Reflux; Dean-Stark; Inert atmosphere
2.1: bromine; phosphorus / 16 h / Inert atmosphere; Reflux
3.1: sodium hydroxide / water / 0.5 h / 40 °C / Inert atmosphere
3.2: 6 h / pH 4 - 5 / Inert atmosphere
4.1: dilauryl peroxide / neat (no solvent) / 85 °C / Sealed tube; Inert atmosphere
5.1: triethylamine; 2,2'-azobis(isobutyronitrile); hypophosphorous acid / water; 1,4-dioxane / Reflux
With
2,2'-azobis(isobutyronitrile); dilauryl peroxide; phosphorus; bromine; hypophosphorous acid; triethylamine; sodium hydroxide;
In
1,4-dioxane; water; toluene;
DOI:10.1021/acs.orglett.0c01087
