tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Base Information

Chemical Name:tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate
CAS No.:1593269-66-9
Molecular Formula:C₃₃H₃₉FN₂O₅
Molecular Weight:562.681
Hs Code.:

Synonyms:tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

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Chemical Property of tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

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Technology Process of tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

There total 3 articles about tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 908598-34-5
C₂₂H₃₁NO₄

: 625826-69-9
4-(chloromethyl)-2-(4-fluorophenyl)-5-methyl-1,3-oxazole

: 1593269-66-9
tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 109544-28-7
2-(4-fluorophenyl)-4,5-dimethyloxazole 3-oxide

: 1593269-66-9
tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 40 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1593269-66-9
tert-butyl 2-(4-{[{[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl] methyl}(furan-2-ylmethyl) amino] methyl}-2,6-dimethylphenoxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 0 - 20 °C

2: trichlorophosphate / acetonitrile / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 40 °C

With hydrogenchloride; potassium carbonate; trichlorophosphate; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513