trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone

Base Information

• Chemical Name: trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone
• CAS No.: 127280-11-9
• Molecular Formula: C₁₇H₁₈N₂O₂
• Molecular Weight: 282.342
• Mol file: 127280-11-9.mol

Synonyms:trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone

Chemical Property of trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone

There total 1 articles about trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-N,N-dimethyl-N'-(3-phenyl-allylidene)-hydrazine (15023-38-8) + p-benzoquinone (106-51-4) → cis-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone (127280-12-0) + trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone (127280-11-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 23 ℃; for 20h; other (E)-2-alkenal N,N-dimethylhydrazones;

DOI:10.1021/jo00301a009

Reference yield: 67.0%

trans-2,3-Dihydro-5-hydroxy-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone (127280-11-9) + acetic anhydride (108-24-7) → trans-(5-Acetyloxy)-2,3-Dihydro-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone (127280-21-1)

Guidance literature:

With pyridine; In dichloromethane; at 23 ℃; for 20h;

DOI:10.1021/jo00301a009

upstream raw materials:

(2E)-N,N-dimethyl-N'-(3-phenyl-allylidene)-hydrazine

p-benzoquinone

Downstream raw materials:

trans-(5-Acetyloxy)-2,3-Dihydro-3-phenylbenzofuran-2-carboxaldehyde N,N-dimethylhydrazone