Technology Process of (-)-9-(t-butyldimethylsilyloxy) glyceollin I
There total 1 articles about (-)-9-(t-butyldimethylsilyloxy) glyceollin I which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate / acetone / Reflux; Inert atmosphere
3.1: acetonitrile / Inert atmosphere
4.1: potassium tert-butylate / methanol / Inert atmosphere; Reflux
5.1: triphenylphosphine hydrobromide / dichloromethane / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: osmium(VIII) oxide; hydroquinidine 1 4-phthalazinediyl diether / dichloromethane / -20 °C
7.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 0 - 20 °C / 1810.07 Torr
8.1: 3-Methylpyridine / para-xylene / 18 h / 120 °C / Inert atmosphere
With
sodium tetrahydroborate; osmium(VIII) oxide; hydroquinidine 1 4-phthalazinediyl diether; 3-Methylpyridine; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; triphenylphosphine hydrobromide; potassium carbonate;
In
methanol; ethanol; dichloromethane; para-xylene; acetone; acetonitrile;
4.1: Wittig reaction / 6.1: Sharpless dihydroxylation;
DOI:10.1021/op200112g
- Guidance literature:
-
With
triethylamine tris(hydrogen fluoride);
In
pyridine; dichloromethane;
at 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/op200112g
