3-MALEIMIDO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY

Base Information

• Chemical Name: 3-MALEIMIDO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY
• CAS No.: 5389-27-5
• Molecular Formula: C₁₂H₁₇N₂O₃
• Molecular Weight: 237.279
• Hs Code.: 2925190090
• Mol file: 5389-27-5.mol

Synonyms:1-Pyrrolidinyloxy,3-maleimido-2,2,5,5-tetramethyl- (7CI,8CI); 2,2,5,5-Tetramethylpyrrolidine-1-oxyl-3-maleimide;2,2,5,5-Tetramethylpyrrolidinyl-1-oxy-3-maleimide;3-Maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxy;3-Maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl;3-Maleimido-2,2,5,5-tetramethylpyrrolidine-N-oxyl; 3-Maleimidoproxyl; A25337-5; MAL 3; N-(1-Oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide;N-(2,2,5,5-Tetramethyl-1-oxylpyrrolidone)-3-maleimide

Chemical Property of 3-MALEIMIDO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY

Chemical Property:

• Appearance/Colour: yellow to orange powder
• Vapor Pressure: 3.43E-06mmHg at 25°C
• Melting Point: 111-113 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 40.62000
• Density: g/cm³
• LogP: 0.76420
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

≥95% ^*data from raw suppliers

3-Maleimido-PROXYL ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Spin label used for study of local protein structure and for determining molecular changes in erythrocyte membranes.

Technology Process of 3-MALEIMIDO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY

There total 1 articles about 3-MALEIMIDO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-maleimido-(2,2,5,5-tetramethyl-1-pyrrolidinyloxy) (5389-27-5)

Guidance literature:

II, Ac2O;

DOI:10.1073/pnas.55.1.8

Refernces

Determination of the binding site of chloro(triethylphosphine)gold(I) in serum albumin

10.1016/j.molstruc.2010.02.053

The study investigates the binding site of chloro(triethylphosphine)gold(I) (ClAuPEt3) in bovine serum albumin (BSA) using electron paramagnetic resonance (EPR) spectroscopy. The researchers employed 3-maleimidoPROXYL as a spin marker to identify the binding site of ClAuPEt3. They found that ClAuPEt3 competes with the spin marker for binding to the cysteine residue (Cys-34) in BSA. At low ClAuPEt3:BSA molar ratios, the spin marker with weak rotational limitation is more easily displaced than the strongly immobilized marker. However, as the ClAuPEt3:BSA molar ratio increases, the displacement of the strongly immobilized marker becomes more prevalent. The study suggests that ClAuPEt3 binding induces conformational changes in BSA, particularly affecting the Cys-34 residue. The findings provide insights into the interaction between gold compounds and serum albumin, which is relevant for understanding drug transport and therapeutic applications of gold(I) complexes in antirheumatic therapy.

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