4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide
• CAS No.: 1256846-72-6
• Molecular Formula: C₂₀H₁₅N₅O₂S₂
• Molecular Weight: 421.503

Synonyms:4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

Chemical Property of 4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

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Technology Process of 4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

There total 1 articles about 4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(2-oxo-2-phenylethylamino)-N-(thiazol-2-yl)benzene-sulfonamide (1256846-70-4) + malononitrile (109-77-3) → 4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide (1256846-72-6)

Guidance literature:

With sodium ethanolate; In ethanol; for 3h; Reflux;

DOI:10.1016/j.bmcl.2010.08.005

Reference yield: 95.0%

4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide (1256846-72-6) + thiourea (17356-08-0) → 4-(4-amino-5-phenyl-2-thioxo-1H-pyrrolo[2,3-d]pyrimidin-7(2H)-yl)-N-(thiazol-2-yl)benzenesulfonamide (1256846-90-8)

Guidance literature:

at 220 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2010.08.005

Reference yield: 91.0%

4-(2-amino-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide (1256846-72-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-(4-amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(thiazol-2-yl)benzenesulfonamide (1256846-76-0)

Guidance literature:

for 5h; Reflux;

DOI:10.1016/j.bmcl.2010.08.005

upstream raw materials:

4-(2-oxo-2-phenylethylamino)-N-(thiazol-2-yl)benzene-sulfonamide

malononitrile

Downstream raw materials:

4-(2-(4-amino-4-oxobutanoic acid-4-yl)-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

4-(3-cyano-2-(2,5-dioxopyrrolidin-1-yl)-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

4-(4-oxo-5-phenyl-3H-pyrrolo[2,3-d]pyrimidin-7(4H)-yl)-N-(thiazol-2-yl)benzenesulfonamide

4-(2-acetamide-3-cyano-4-phenyl-1H-pyrrol-1-yl)-N-(thiazol-2-yl)benzenesulfonamide

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