(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

Base Information

Chemical Name:(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone
CAS No.:213992-79-1
Molecular Formula:C₃₄H₅₂O₃Si₂
Molecular Weight:564.956
Hs Code.:

Synonyms:(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

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Chemical Property of (2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

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Technology Process of (2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

There total 6 articles about (2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 213992-93-9
(1S,2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanol

: 213992-79-1
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

Guidance literature:: Dess-Martin oxid.;
DOI:10.1016/S0040-4039(98)01409-9

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 213992-79-1
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / imid. / dimethylformamide / 2 h / Ambient temperature

2: 80 percent / MsCl, Et₃N, DMAP / 2 h / -78 deg C to RT

3: 80 percent / hydroxylamine, ethyl acetate / dimethylformamide / 10 h / 95 °C

4: 95 percent / cyclohexene / 20percent Pd(OH)2/C / ethanol / 5 h / Heating

5: 80 percent / Dess-Martin oxid.

With 1H-imidazole; dmap; hydroxylamine; ethyl acetate; methanesulfonyl chloride; triethylamine; cyclohexene; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01409-9

Reference yield:

: 213995-17-6
3-[1-[(1R,2S,5S)-2-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-cyclopentyl]-meth-(E)-ylidene]-4-methyl-pentane-1,4-diol

: 213992-79-1
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-{(E)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-but-1-enyl}-cyclopentanone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / imid. / dimethylformamide / 2 h / Ambient temperature

2: 80 percent / MsCl, Et₃N, DMAP / 2 h / -78 deg C to RT

3: 80 percent / hydroxylamine, ethyl acetate / dimethylformamide / 10 h / 95 °C

4: 95 percent / cyclohexene / 20percent Pd(OH)2/C / ethanol / 5 h / Heating

5: 80 percent / Dess-Martin oxid.

With 1H-imidazole; dmap; hydroxylamine; ethyl acetate; methanesulfonyl chloride; triethylamine; cyclohexene; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01409-9