(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide

Base Information

• Chemical Name: (2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide
• CAS No.: 1010689-18-5
• Molecular Formula: C₃₄H₃₄O₇
• Molecular Weight: 554.64
• Mol file: 1010689-18-5.mol

Synonyms:(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide

Chemical Property of (2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide

There total 1 articles about (2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-pivaloyloxymethyl-4-butanolide (868128-04-5) → (2R,3S)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-4-butanolide (1010689-16-3) + (2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide (1010689-18-5)

Guidance literature:

(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-pivaloyloxymethyl-4-butanolide; With sodium hydroxide; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; In ethanol; Further stages.;

DOI:10.1271/bbb.70168

Reference yield: 23.0%

(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide (1010689-18-5) → (2R,3S)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-4-butanolide (1010689-16-3)

Guidance literature:

(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide; With sodium hydroxide; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; In ethanol; Further stages.;

DOI:10.1271/bbb.70168

Reference yield:

(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-4-butanolide (1010689-18-5) → (2R,3S)-2,3-bis(4-hydroxy-3-methoxybenzyl)-4-butanolide

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaOH / ethanol / 16 h / 20 °C

1.2: 23 percent / aq. HCl / ethanol

2.1: 85 percent / H₂ / Pd(OH)2/C / ethyl acetate / 50 h / 20 °C

With sodium hydroxide; hydrogen; palladium dihydroxide; In ethanol; ethyl acetate;

DOI:10.1271/bbb.70168

upstream raw materials:

(2R,3S,4S)-2-(4-benzyloxy-3-methoxybenzyl)-4-(4-benzyloxy-3-methoxyphenyl)-3-pivaloyloxymethyl-4-butanolide

Downstream raw materials:

(2R,3S)-2-(4-benzyloxy-3-methoxybenzyl)-3-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-4-butanolide