2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

Base Information

Chemical Name:2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide
CAS No.:1562665-16-0
Molecular Formula:C₂₃H₂₀N₄O₅S₂
Molecular Weight:496.568
Hs Code.:

Synonyms:2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

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Chemical Property of 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

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Technology Process of 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

There total 5 articles about 2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 10147-70-3
2-chloro-N-(2-nitrophenyl)acetamide

: 1562664-75-8
1-[(3,5-dimethylphenyl)sulfonyl]-1,3-dihydro-2Hbenzimidazole-2-thione

: 1562665-16-0
2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.12.045

Reference yield:

: 88-74-4
2-nitro-aniline

: 1562665-16-0
2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.045

Reference yield:

: 2905-27-3
3,5-dimethyl-benzenesulfonyl chloride

: 1562665-16-0
2-({1-[(3,5-dimethylphenyl)sulfonyl]-1H-benzimidazol-2-yl}sulfanyl)-N-2-nitrophenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2: hydrogenchloride; zinc / ethanol / 1 h / Reflux

3: pyridine / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; zinc; In pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.12.045