methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate
CAS No.:150461-47-5
Molecular Formula:C₂₅H₂₈ClNO₃S
Molecular Weight:458.021
Hs Code.:

Synonyms:methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Suppliers and Price of methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

There total 5 articles about methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 147961-30-6
methyl 3-<3-(tert-butylthio)-1-(4-chlorobenzyl)-4-crotyl-5-hydroxyindol-2-yl>-2,2-dimethylpropanoate

: 150461-47-5
methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; for 2h; Heating;
DOI:10.1021/jm00071a008

Reference yield:

: 20955-94-6
1-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)-hydrazine hydrochloride

: 150461-47-5
methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / NaOAc, glacial AcOH / toluene / 72 h / Ambient temperature

2: 1 N LiOH / methanol; tetrahydrofuran / 3 h / 80 °C

3: 78 percent / tert-butylthiol, NaH, HMPA / 5 h / 175 °C

4: 1.) KH, 2.) ZnCl₂ / 1.) p-xylene, reflux, 20 min, 2.) p-xylene, reflux, 1 h, 3.) RT, overnight

5: 73 percent / p-toluenesulfonic acid / 1,2-dichloro-ethane / 2 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; sodium acetate; potassium hydride; sodium hydride; toluene-4-sulfonic acid; 2-methylpropan-2-thiol; acetic acid; zinc(II) chloride; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm00071a008

Reference yield:

: methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate

: 150461-47-5
methyl 3-<1-(4-chlorobenzyl)-4-ethyl-5-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / NaOAc, glacial AcOH / toluene / 72 h / Ambient temperature

2: 1 N LiOH / methanol; tetrahydrofuran / 3 h / 80 °C

3: 78 percent / tert-butylthiol, NaH, HMPA / 5 h / 175 °C

4: 1.) KH, 2.) ZnCl₂ / 1.) p-xylene, reflux, 20 min, 2.) p-xylene, reflux, 1 h, 3.) RT, overnight

5: 73 percent / p-toluenesulfonic acid / 1,2-dichloro-ethane / 2 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; sodium acetate; potassium hydride; sodium hydride; toluene-4-sulfonic acid; 2-methylpropan-2-thiol; acetic acid; zinc(II) chloride; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm00071a008