4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine

Base Information

• Chemical Name: 4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine
• CAS No.: 63038-77-7
• Molecular Formula: C₁₉H₂₆N₆OS₂
• Molecular Weight: 418.587

Synonyms:4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine

Chemical Property of 4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine

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Technology Process of 4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine

There total 6 articles about 4'c-benzyloxymethyl-(3'ar,10'atN^1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyloxyacetoaldehyde (60656-87-3) → 4'c-benzyloxymethyl-(3'ar,10'atN1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine (63038-77-7)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene

2: (i) N₂H₄*H₂O, MeOH, (ii) NOCl, CH₂Cl₂, , (iii) benzene, (iv) NH₃

3: BF₃*Et₂O / acetonitrile

4: acetic acid; trifluoroacetic acid

5: (i) Et₃O⁽¹⁺⁾*BF₄^(1-), NaHCO₃, CH₂Cl₂, (ii) EtCO₂NH₄

With boron trifluoride diethyl etherate; In acetic acid; acetonitrile; trifluoroacetic acid; benzene;

DOI:10.1021/ja00450a079

Reference yield:

(6,10-dioxa-2-aza-spiro[4.5]dec-1-ylidene)-acetic acid methyl ester (62987-19-3) → 4'c-benzyloxymethyl-(3'ar,10'atN1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine (63038-77-7)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene

2: (i) N₂H₄*H₂O, MeOH, (ii) NOCl, CH₂Cl₂, , (iii) benzene, (iv) NH₃

3: BF₃*Et₂O / acetonitrile

4: acetic acid; trifluoroacetic acid

5: (i) Et₃O⁽¹⁺⁾*BF₄^(1-), NaHCO₃, CH₂Cl₂, (ii) EtCO₂NH₄

With boron trifluoride diethyl etherate; In acetic acid; acetonitrile; trifluoroacetic acid; benzene;

DOI:10.1021/ja00450a079

Reference yield:

3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester (62987-20-6) → 4'c-benzyloxymethyl-(3'ar,10'atN1')-3'a,4',8',9'-tetrahydro-1'(3')H-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purine]-2',6'-diamine (63038-77-7)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) N₂H₄*H₂O, MeOH, (ii) NOCl, CH₂Cl₂, , (iii) benzene, (iv) NH₃

2: BF₃*Et₂O / acetonitrile

3: acetic acid; trifluoroacetic acid

4: (i) Et₃O⁽¹⁺⁾*BF₄^(1-), NaHCO₃, CH₂Cl₂, (ii) EtCO₂NH₄

With boron trifluoride diethyl etherate; In acetic acid; acetonitrile; trifluoroacetic acid;

DOI:10.1021/ja00450a079

upstream raw materials:

4'c-benzyloxymethyl-6'-thioxo-(3'ar,10'atN¹)-hexahydro-spiro[[1,3]dithiane-2,10'-pyrrolo[1,2-c]purin]-2'-one

benzyloxyacetoaldehyde

(6,10-dioxa-2-aza-spiro[4.5]dec-1-ylidene)-acetic acid methyl ester

3'-benzyloxymethyl-1'-thioxo-2',3',6',7'-tetrahydro-1'H-spiro[[1,3]dioxane-2,5'-pyrrolo[1,2-c]pyrimidine]-4'-carboxylic acid methyl ester

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