ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

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Chemical Name:ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate
CAS No.:1621421-92-8
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

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Chemical Property of ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

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Technology Process of ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

There total 7 articles about ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1621421-90-6
ethyl 2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

: 107-30-2
chloromethyl methyl ether

: 1621421-92-8
ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

Guidance literature:: ethyl 2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃; for 0.666667h; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; at -40 - 20 ℃; for 12.1667h; Inert atmosphere;

Reference yield:

: 1621421-76-8
1-(tert-butoxycarbonyl) 2-(methoxycarbonyl)pyrrolidine-2-carboxylic acid

: 1621421-92-8
ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

2.1: lithium bromide; sodium tetrahydroborate / methanol / 12 h

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication

4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 12 h / 70 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -40 °C / Inert atmosphere

6.2: 12.17 h / -40 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; lithium bromide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1621421-80-4
tert-butyl 2-(hydroxymethyl)-2-(4-methoxyphenylcarbamoyl)pyrrolidine-1-carboxylate

: 1621421-92-8
ethyl 2-methoxy-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: potassium carbonate / acetonitrile / 12 h / 70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -40 °C / Inert atmosphere

4.2: 12.17 h / -40 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;