cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate

Base Information

• Chemical Name: cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate
• CAS No.: 1421231-51-7
• Molecular Formula: C₁₅H₂₈O₃Si
• Molecular Weight: 284.471
• Mol file: 1421231-51-7.mol

Synonyms:cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate

Chemical Property of cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate

Chemical Property:

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Technology Process of cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate

There total 1 articles about cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-cyclohexene-1-methanol (4845-04-9) + 2-((tert-butyldimethylsilyl)oxy)acetyl chloride (78826-45-6) → cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate (1421231-51-7)

Guidance literature:

With pyridine; tert-butyldimethylsilyl chloride; In diethyl ether; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo302467w

Reference yield: 89.0%

cyclohex-1-en-1-ylmethyl 2-[(tert-butyldimethylsilyl)oxy]-acetate (1421231-51-7) → 2-[(tert-butyldimethylsilyl)oxy]-2-(2-methylidenecyclohexyl)acetic acid

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; tert-butyldimethylsilyl chloride; triethylamine; diisopropylamine; In tetrahydrofuran; at -78 - 25 ℃; for 24.0833h; Inert atmosphere;

DOI:10.1021/jo302467w

upstream raw materials:

1-cyclohexene-1-methanol

2-((tert-butyldimethylsilyl)oxy)acetyl chloride