carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester

Base Information

• Chemical Name: carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester
• CAS No.: 643746-52-5
• Molecular Formula: C₁₈H₂₄O₈
• Molecular Weight: 368.384
• Mol file: 643746-52-5.mol

Synonyms:carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester

Chemical Property of carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester

There total 1 articles about carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester (643746-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / AlCl₃ / CH₂Cl₂ / 3 h / 20 °C

2: 82 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; aluminium trichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1055/s-2003-42059

Reference yield: 90.0%

(R)-α-methylbenzyl vinyl ether (28084-56-2) + carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester (643746-52-5) → carbonic acid tert-butyl ester 6-methoxy-4-phenyl-2-(1-phenyl-ethoxy)-chroman-7-yl ester

Guidance literature:

In diethyl ether; at -78 - 20 ℃; for 3h;

DOI:10.1021/jo048703c

Reference yield: 80.0%

(R)-α-methylbenzyl vinyl ether (28084-56-2) + carbonic acid 5-tert-butoxycarbonyloxy-2-formyl-4-methoxy-phenyl ester tert-butyl ester (643746-52-5) → carbonic acid tert-butyl ester 6-methoxy-4-methyl-2-(1-phenyl-ethoxy)-chroman-7-yl ester

Guidance literature:

In diethyl ether; at -78 - 20 ℃; for 3h;

DOI:10.1021/jo048703c

upstream raw materials:

asaraldehyde

Downstream raw materials:

carbonic acid tert-butyl ester 5-hydroxy-2-methoxy-4-(1-phenyl-allyl)-phenyl ester