Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

Base Information

Chemical Name:Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester
CAS No.:908150-04-9
Molecular Formula:C₂₃H₂₇NO₉
Molecular Weight:461.469
Hs Code.:

Synonyms:Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

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Chemical Property of Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

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Technology Process of Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

There total 6 articles about Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908149-94-0
(1S,4R,5S)-N-(3,4-dimethoxyphenylacetyl)-1-acetoxy-6-azaspiro[4.4]non-2-en-4-ol

: 5781-53-3
monomethyl oxalyl chloride

: 908150-04-9
Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 96h;
DOI:10.1016/j.tet.2006.05.045

Reference yield:

: 908149-93-9
Acetic acid (5S,6S,9R)-9-hydroxy-1-aza-spiro[4.4]non-7-en-6-yl ester

: 908150-04-9
Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / acetonitrile / 1.17 h / -40 °C

2: DMAP / CH₂Cl₂ / 96 h / 20 °C

With dmap; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.05.045

Reference yield:

: 908149-92-8
1,4-diacetoxy-6-azaspiro[4.4]non-2-ene

: 908150-04-9
Oxalic acid (5R,6R,9S)-9-acetoxy-1-[2-(3,4-dimethoxy-phenyl)-acetyl]-1-aza-spiro[4.4]non-7-en-6-yl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; lyophilized electric eel acetyl cholinesterase; sodium dihydrogen phosphate / pH 6.9

2: 80 percent / triethylamine / acetonitrile / 1.17 h / -40 °C

3: DMAP / CH₂Cl₂ / 96 h / 20 °C

With dmap; sodium azide; sodium dihydrogen phosphate; lyophilized electric eel acetyl cholinesterase; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2006.05.045