7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Base Information

• Chemical Name: 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester
• CAS No.: 1155712-58-5
• Molecular Formula: C₂₂H₂₃N₃O₄S₂
• Molecular Weight: 457.574
• Mol file: 1155712-58-5.mol

Synonyms:7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Chemical Property of 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester

There total 1 articles about 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride + 4-aminotiophenol (1193-02-8) → 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester (1155712-58-5)

Guidance literature:

para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

4-aminotiophenol; With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/anie.200804804

Reference yield: 57.06%

2-oxo-2H-chromene-3-carboxylic acid (531-81-7) + 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester (1155712-58-5) → C42H31N3O10S2 (1426300-06-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.1016/j.bmcl.2013.01.071

Reference yield: 53.0%

5-(4'-carboxybutylamino)-9-diethylaminobenzo[a]phenothiazinium chloride (1182337-30-9) + 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester (1155712-58-5) → C72H73N9O6S4 (1155712-62-1)

Guidance literature:

5-(4'-carboxybutylamino)-9-diethylaminobenzo[a]phenothiazinium chloride; 7-amino-3-(4-aminophenylthio)methyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester; With HATU; In N,N-dimethyl-formamide; for 1h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;

DOI:10.1002/anie.200804804

upstream raw materials:

4-aminotiophenol

Downstream raw materials:

C₇₂H₇₃N₉O₆S₄

C₄₂H₃₁N₃O₁₀S₂

N-(4-mercaptophenyl)-2-oxo-2H-chromene-3-carboxamide