(4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

Base Information

Chemical Name:(4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester
CAS No.:765300-63-8
Molecular Formula:C₃₃H₄₄O₄Si
Molecular Weight:532.795
Hs Code.:

Synonyms:(4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

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Chemical Property of (4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

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Technology Process of (4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

There total 6 articles about (4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 765300-62-7
(E)-(4R,6S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octa-2,7-dienoic acid ethyl ester

: 765300-63-8
(4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.1016/j.tetasy.2004.06.023

Reference yield:

: 96852-88-9
3,5,6-trideoxy-1,2-O-isopropylidene-α-D-ribo-hex-5-enofuranoside

: 765300-63-8
(4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 79 percent / H₂SO₄ / 12 h / 60 °C

2: 75 percent / NaH / tetrahydrofuran / 6 h / 20 °C

3: 90 percent / H₂SO₄; aq. AcOH / 12 h / 60 °C

4: 90 percent / NaBH₄ / methanol / 1 h / 20 °C

5: 78 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

6: 70 percent / imidazole / CH₂Cl₂ / 4 h / 20 °C

7: 74 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

8: 91 percent / IBX / dimethylsulfoxide / 6 h / 20 °C

9: 79 percent / benzene / 1 h / 80 °C

10: 90 percent / H₂ / PtO₂ / ethyl acetate / 12 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; sulfuric acid; hydrogen; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1016/j.tetasy.2004.06.023

Reference yield:

: 258873-39-1
[(3R,5S)-2-methoxy-5-vinyltetrahydrofuran-3-ol]

: 765300-63-8
(4S,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / NaH / tetrahydrofuran / 6 h / 20 °C

2: 90 percent / H₂SO₄; aq. AcOH / 12 h / 60 °C

3: 90 percent / NaBH₄ / methanol / 1 h / 20 °C

4: 78 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

5: 70 percent / imidazole / CH₂Cl₂ / 4 h / 20 °C

6: 74 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

7: 91 percent / IBX / dimethylsulfoxide / 6 h / 20 °C

8: 79 percent / benzene / 1 h / 80 °C

9: 90 percent / H₂ / PtO₂ / ethyl acetate / 12 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; sulfuric acid; hydrogen; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1016/j.tetasy.2004.06.023