Technology Process of (4bS,8aS,9S)-benzyl 3-(benzyloxy)-1-bromo-2-((1-ethoxy-1-oxopropan-2-yl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
There total 7 articles about (4bS,8aS,9S)-benzyl 3-(benzyloxy)-1-bromo-2-((1-ethoxy-1-oxopropan-2-yl)amino)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride; sodium iodide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 120h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydroxide / 1,4-dioxane; water / 20 °C / Inert atmosphere
2: nitric acid; formic acid / 20 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere
4: hydrazine hydrate / Raney Ni / water; methanol / 2 h / 20 °C / Inert atmosphere
5: pyridinium hydrobromide perbromide / tetrahydrofuran / 60 °C / Inert atmosphere
6: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 120 h / 80 °C / Inert atmosphere
With
formic acid; pyridinium hydrobromide perbromide; nitric acid; sodium hydride; potassium carbonate; hydrazine hydrate; sodium iodide; sodium hydroxide;
Raney Ni;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: nitric acid; formic acid / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere
3: hydrazine hydrate / Raney Ni / water; methanol / 2 h / 20 °C / Inert atmosphere
4: pyridinium hydrobromide perbromide / tetrahydrofuran / 60 °C / Inert atmosphere
5: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 120 h / 80 °C / Inert atmosphere
With
formic acid; pyridinium hydrobromide perbromide; nitric acid; sodium hydride; potassium carbonate; hydrazine hydrate; sodium iodide;
Raney Ni;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
