4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide

Base Information

• Chemical Name: 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide
• CAS No.: 1168138-64-4
• Molecular Formula: C₂₃H₂₁Cl₂N₃O₃
• Molecular Weight: 458.344
• Mol file: 1168138-64-4.mol

Synonyms:4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide

Chemical Property of 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide

There total 3 articles about 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-3-nitro-N-[(1R)-1-phenylpropyl]benzamide (1168138-38-2) + 3,4-dichlorobenzyl amine (102-49-8) → 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide (1168138-64-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide (1168138-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 21 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / Reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.088

Reference yield:

1-phenylpropylamine (2941-20-0,3082-64-2,3789-59-1,35600-74-9) → 4-{[(3,4-dichlorophenyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide (1168138-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 21 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 17 h / Reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.088

upstream raw materials:

4-fluoro-3-nitro-N-[(1R)-1-phenylpropyl]benzamide

3,4-dichlorobenzyl amine

3-nitro-4-fluorobenzoic acid

1-phenylpropylamine

Downstream raw materials:

1-[(3,4-dichlorophenyl)methyl]-N-[(1R)-1-phenylpropyl]-1H-benzimidazole-5-carboxamide

3-amino-4-{[(3,4-dichlorophenyl)methyl]amino}-N-[(1R)-1-phenylpropyl]benzamide