Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

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Chemical Name:Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid
CAS No.:167027-19-2
Molecular Formula:C₃₆H₃₂O₁₂
Molecular Weight:656.643
Hs Code.:

Synonyms:Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

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Chemical Property of Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

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Technology Process of Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

There total 6 articles about Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 867296-31-9
p-hydroxycinnamoylfilicinic acid

: 298-12-4
Glyoxilic acid

: 167027-19-2
Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2005.07.080

Reference yield:

: 867296-34-2
3-Hydroxy-2-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-5-methoxy-4,4-dimethyl-cyclohexa-2,5-dienone

: 167027-19-2
Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 15 percent / HBr / acetic acid / 0.5 h / 70 °C

2: 60 percent / sodium methoxide / methanol / 1 h / 20 °C

3: 99 percent / sodium methoxide / methanol / 4 h / 20 °C

With hydrogen bromide; sodium methylate; In methanol; acetic acid;
DOI:10.1016/j.tet.2005.07.080

Reference yield:

: 16302-39-9
2-acetyl-3,5-dihydroxy-4,4-dimethyl-2,5-cyclohexadien-1-one

: 167027-19-2
Bis-{2,4-dihydroxy-5-[(E)-3-(4-hydroxy-phenyl)-acryloyl]-3,3-dimethyl-6-oxo-cyclohexa-1,4-dienyl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / piperidine / 1 h / 80 °C

2: 15 percent / HBr / acetic acid / 0.5 h / 70 °C

3: 60 percent / sodium methoxide / methanol / 1 h / 20 °C

4: 99 percent / sodium methoxide / methanol / 4 h / 20 °C

With piperidine; hydrogen bromide; sodium methylate; In methanol; acetic acid;
DOI:10.1016/j.tet.2005.07.080