4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

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Chemical Name:4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide
CAS No.:1607005-21-9
Molecular Formula:C₂₉H₃₀FN₅O₃
Molecular Weight:515.587
Hs Code.:

Synonyms:4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

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Chemical Property of 4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

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Technology Process of 4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

There total 10 articles about 4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 110-91-8,99108-56-2
morpholine

: 1607005-20-8
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

: 1607005-21-9
4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 1607005-21-9
4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 48 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 150 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1607005-19-5
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid tert-butyl ester

: 1607005-21-9
4-tert-butyl-N-(2-fluoro-4-(6-(morpholine-4-carbonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;