di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate
• CAS No.: 1614215-38-1
• Molecular Formula: C₂₁H₂₆N₄O₄
• Molecular Weight: 398.462

Synonyms:di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate

Chemical Property of di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate

Chemical Property:

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Technology Process of di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate

There total 1 articles about di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(2-phenylethynyl)-1H-imidazole (1046136-03-1) + di-tert-butyl-diazodicarboxylate (870-50-8) → di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate (1614215-38-1)

Guidance literature:

1-(2-phenylethynyl)-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; at -78 - -60 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2014.04.099

Reference yield: 90.0%

di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate (1614215-38-1) → di-tert-butyl 3-phenylimidazo[2,1-c][1,2,4]triazine-1,2-dicarboxylate (1614215-40-5)

Guidance literature:

With potassium phosphate; In toluene; for 14h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2014.04.099

Reference yield: 85.0%

di-tert-butyl 1-(1-(phenylethynyl)-1H-imidazol-2-yl)hydrazine-1,2-dicarboxylate (1614215-38-1) → (Z)-di-tert-butyl 3-benzylidene-1H-imidazo[2,1-c][1,2,4]triazole-1,2(3H)-dicarboxylate (1614215-39-2)

Guidance literature:

With sodium t-butanolate; In tert-butyl alcohol; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tet.2014.04.099

upstream raw materials:

1-(2-phenylethynyl)-1H-imidazole

di-tert-butyl-diazodicarboxylate

Downstream raw materials:

(Z)-di-tert-butyl 3-benzylidene-1H-imidazo[2,1-c][1,2,4]triazole-1,2(3H)-dicarboxylate

di-tert-butyl 3-phenylimidazo[2,1-c][1,2,4]triazine-1,2-dicarboxylate

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