5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

Base Information

Chemical Name:5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate
CAS No.:1609492-09-2
Molecular Formula:C₂HF₃O₂*C₂₀H₂₃ClN₆O
Molecular Weight:512.919
Hs Code.:

Synonyms:5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

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Chemical Property of 5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

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Technology Process of 5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

There total 4 articles about 5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1232223-41-4
2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-5-chloro-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine

: 76-05-1
trifluoroacetic acid

: 1609492-09-2
5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.036

Reference yield:

: 78583-82-1
3-amino-5-(4-bromophenyl)-1H-pyrazol

: 1609492-09-2
5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 0.83 h / 150 °C / Microwave irradiation; Inert atmosphere

1.2: 7 h / Cooling with ice; Reflux; Inert atmosphere

2.1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.1: sodium t-butanolate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; sodium ethanolate; sodium t-butanolate; In 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2014.03.036

Reference yield:

: 1232223-32-3
2-(4-bromophenyl)-5-chloro-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine

: 1609492-09-2
5-chloro-7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

2: dichloromethane / 1 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; sodium t-butanolate; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2014.03.036